Tuong lai cua dieu tri ung thu da day da den:
Lieu phap nham dich CLDN18.2 va CAR-T khoi u dac

THUONG HAI— Bai canh dieu tri ung thu da day bang thuoc dang trai qua mot cuoc chuyen doi co cau. Ky nguyen cua hoa tri nhu lua chon duy nhat dang ket thuc. Khi phan nhom phan tu tro thanh tieu chuan, cac lieu phap dot pha nham vao cac chi diem sinh hoc cu the dang xuat hien — va hai trong so nhung dot pha duoc theo doi sat nhat gio day chia se cung mot muc tieu:CLDN18.2.

Zolbetuximab (佐妥昔单抗) vua cong bo giam gia gan 30%, va Satri-cel (舒瑞基奥仑赛 / CT041), lieu phap CAR-T khoi u dac dau tien the gioi, dang gan duoc phe duyet tai Trung Quoc. Ca hai deu da co san — hoac se som co — taiTrung tâm Ung thư Quốc tế Jiahui.

CLDN18.2 la gi?

CLDN18.2 (Claudin 18.2) la mot protein mang ket noi duoc bieu hien manh o nhieu khoi u dac, dac biet la ung thu da day, ung thu tuyen noi tiep da day - thuc quản (GEJ) va mot so loai ung thu phoi.

Đoi voi cacbenh nhan duong tinh CLDN18.2, am tinh HER2, cac lua chon dieu tri da bi han che nghiem trong trong nhieu nam. Dieu do da thay doi — mot cach manh me.

Zolbetuximab (佐妥昔单抗): tieu chuan moi cho tuyen dau

Benh nhan dap ung dieu kien

Xac nhan qua xet nghiem hoa mo miem dich (IHC):

• CLDN18.2 duong tinh(≥75% te bao u voi cuong do nhuom mang ≥2+)
• HER2 am tinh
• Ung thu tuyen da day / GEJ tien trien tai cho khong the cat bo hoac di can —dieu tri tuyen dau

Hieu qua lam sang

Du lieu thu nghiem lam sang cho thay zolbetuximab keo dai dang ke thoi gian song con toan bo trung vi (mOS) len18,2 thang, approaching 2 years in the per-protocol set (PPS) [1]. Notably, in the Chinese subgroup analysis, the risk of disease progression or death was reduced to 52%, demonstrating even greater clinical benefit for Asian patients [2].

"Zolbetuximab da cong bo giam gia gan 30%. De cai thien kha nang tiep can dieu tri cho benh nhan dap ung dieu kien, Shanghai Jiahui International Cancer Center da dieu chinh gia ngay lap tuc."Gia moi nhat: 2.790 CNY moi lo 100mg."

Quan trong:Zolbetuximab co lien quan den buon non va non. Tai Jiahui, doi ngu lam sang giau kinh nghiem ap dung cac quy trinh chong non phong ngu va dieu chinh ca nhan toc do truyend de giam dang ke ty le cac dot non do grade 3-4.

Satri-cel (舒瑞基奥仑赛 / CT041): lieu phap CAR-T khoi u dac nham dich CLDN18.2 dau tien the gioi

Lieu phap tế bao CAR-T theo truyen thong chi danh cho cac u ac tinh tao mau. Thang 6 nam 2025, Cuc Quan ly San pham Y te Quoc gia Trung Quoc (NMPA) da tiep nhan Don dang ky thuoc moi (NDA) choSatri-cel (CT041)— lieu phap CAR-T dau tien the gioi nham vao khoi u dac duong tinh CLDN18.2. Viec phe duyet la rat gan.

Benh nhan dap ung dieu kien

Satri-cel (CT041) chi dinh cho benh nhan co:

• bieu hien CLDN18.2 duong tinh(≥40% te bao u voi cuong do nhuom mang ≥2+)
• HER2 am tinh
• ung thu tuyen da day / GEJ tien trien dathat bai it nhat hai phac do truoccua lieu phap toan than

Hieu qua lam sang

In the pivotal CT041-ST-01 study, satri-cel demonstrated statistically significant improvement in progression-free survival (PFS) compared to standard-of-care therapy in CLDN18.2-positive, heavily pretreated G/GEJC patients, with clinically meaningful overall survival (OS) benefit and a manageable safety profile [3].

Cac ket qua nay ung ho satri-cel nhu mot tieu chuan cham soc tuyen ba moi, the hien qua viec dua vao nhu mot khuyen nghi bo sung cho benh nhan da that bai voi cac lieu phap chuan trongHuong dan thuc hanh lam sang ung thu da day CSCO (ban 2026).

"Shanghai Jiahui International Cancer Center da hoan thanh dao tao quy trinh administer Satri-cel (CT041). Khi co giay phep luu hanh chinh thuc, Jiahui se nam trong so"nhung co so y te dau tiende cung cap lieu phap dot pha nay, mang den cac lua chon dieu tri moi cho benh nhan dap ung dieu kien."

Cach lua chon: Zolbetuximab hay Satri-cel

Hai lieu phap nay cung nham vao mot chi diem sinh hoc nhung phuc vu cac tuyen dieu tri khac nhau. Lua chon phu thuoc vao nhieu yeu to can danh gia boi chuyen gia:

Luu y quan trong cho benh nhan

• Xet nghiem truoc.Xet nghiem chi diem sinh hoc CLDN18.2 va HER2 bang IHC la bat buoc truoc khi co the xem xet bat ky lieu phap nao. Jiahui cung cap giai phau benh tai cho voi thoi gian tra ket qua nhanh.
• Danh gia chuyen gia.Sau khi nhan ket qua xet nghiem, hay tham van mot doi ngu ung buou giau kinh nghiem. Tai Jiahui, cac bac si theo doi dong chu dong ve hieu qua va an toan suot qua trinh dieu tri.
• Quan ly da chuyen khoa.Ca hai lieu phap deu can su phoi hop cham soc toan dien — cac duoc si lam sang va doi ngu dieu duong cua chung toi hop tac de quan ly cac tac dung phu va dam bao an toan dieu tri.
• Chon mot trung tam da duoc dao tao.Lieu phap CAR-T dac biet doi hoi kinh nghiem cua co so trong viec quan ly doc tinh cua lieu phap te bao. Jiahui da hoan thanh dao tao chinh thuc quy trinh administer Satri-cel.

Jiahui International Cancer Center: san sang cho ca hai

Jiahui International Cancer Center thuoc Shanghai Jiahui International Hospital, do cac lanh dao lam sang dai dien cho cac tieu chuan quoc te ve cham soc ung buou. Chung toi cung cap cac dich vu ung buou toan dien, tuan thu huong dan, cho benh nhan tu 14 tuoi tro len.

Chuong trinh CAR-T cua chung toi da rat phat trien: Jiahui da dieu tri thanh cong nhieu benh nhan quoc te bang lieu phap CAR-T cho cac u ac tinh tao mau, bao gom benh nhan u lympho va da u tuy noi tiep den tu nuoc ngoai chi de dieu tri tai trung tam cua chung toi. Dieu ho danh gia cao o Jiahui:

• Cơ sở vật chất và năng lực lâm sàng chuẩn quốc tế
• Cham soc ung buou toan dien voi cac doi ngu da chuyen khoa
• Giao tiep xuyen van hoa da ngon ngu (ho tro hon 20 nguon ngu)
• Moi truong dieu tri thoai mai va rieng tu
• Lieu phap CAR-T hieu qua ve chi phi theo tieu chuan quoc te
• Cac quy trinh quan ly doc tinh lieu phap te bao giau kinh nghiem

Gap gom lanh dao ung buou cua chung toi